Hill coefficient is the slope of the relationship between drug concentration and drug effect.
While these examples seem obvious, the administration of the preceding drug examples should be kept in mind so practitioners do not administer these drugs to inhibit platelet aggregation, lower blood pressure or lower blood glucose but to reduce the risks of cerebrovascular accident, myocardial infarction, and renal and eye complications through the drug's pharmacodynamic effects. Examples of this include the (1) inhibition of platelet aggregation after administering aspirin, (2) the reduction of blood pressure after ACE inhibitors, and (3) the blood-glucose-lowering effect of insulin. Subsequent to the drug-target interaction occurring downstream, effects are elicited which can be measured by biochemical or clinical means. Examples of these types of interactions include (1) drugs binding to an active site of an enzyme, (2) drugs that interact with cell surface signaling proteins to disrupt downstream signaling, and (3) drugs that act by binding molecules like tumor necrosis factor (TNF). These interactions include receptor binding, post-receptor effects, and chemical interactions. It comes from the Greek words "pharmakon" meaning "drug" and "dynamikos" meaning "power." All drugs produce their effects by interacting with biological structures or targets at the molecular level to induce a change in how the target molecule functions in regards to subsequent intermolecular interactions. Pharmacodynamics is the study of a drug's molecular, biochemical, and physiologic effects or actions. John Locke Essay Concerning Human Understanding we should be able to tell beforehand that rhubarb will purge, hemlock kill and opium make a man sleepy.” “Did we but know the mechanical affections of the particles of rhubarb, hemlock, opium, and a man.
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